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We can receive mail, and we can access mail via web control panel, but we cannot receive any mail via a mail client (thunderbird, outlook, etc.). I get a "connection refused" error. This only began within the last hour.
When you attempt to recieve email using Outlook what error number do you get? It should start with 0x888cccxx something? Have you tried clearing the outbox? Also, deleting and rebuilding e-mail account? Have you tried using Putty to see if you can duplicate the issue? Send your self a test message within outlook? Just to generate an error number.