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The attacks themselves start with hijacking my browser, then my Stop Sign AV programs are crippled so that I cannot delete the infected files. Then comes the knockout blow. This happens over a period of 5 - 10 days. The last time I couldn't turn my monitor on, or turn off the machine with the front panel button - I had to pull the power cord.
Sounds more like you got coolsearch, sasser, soBig, myDoom and netsky all bundled up together. Do you have a firewall? You might want to invest on a good one if you are running a business. A physical firewall, a software one of the pC and an updated AV seems to do the trick for me...you should try it.