The most effective way to use those valid domain names, ip addresses and phone numbers which spammers can not afford to not to use or fake. Is to build either Mail Server or Mail Client spam filter which goes like this

ACTION = Reject OR Delete
ITEM = Body (email body field)
FUNCTION= Contains String (Sepate with semi-colon)
String=unihere4d.com;trend455fd.com;redstarbar.co.uk;supersavingsonline.biz;entrye3dd.com;trend455fd.com;1-212-330-8202;

FROM NOW ON ANY SPAM EMAIL WHICH CONTAINS THOSE DOMAINS WILL BE AUTOMATICALLY REJECT OR DELETED.

Just imagine if these method would be used in way same way as Anti-virus.

Norton Anti-Spam

->Scan email body for learned span domain names, ip adddresses and phone numbers
->When found delete or quarantine
->Norton Anti-Spam Updates (Downloads the latest spam domain/IP/Telephone list.

YOU GET THE IDEA!!!