did you update and run both adware and spybot ? and was it version 1.3 of spybot the latest ? If so, I'm quite surprised it didn't pick up most of the problems here..

I'm going to point out most of the entries.. but you really should google on many of them.

first and foremost..

O4 - HKLM\..\Run: [Internet Optimizer] "C:\Program Files\Internet Optimizer\optimize.exe"
reference this link
Description: Adult content dialer that dials numbers specific to porn related sites
here's what you should look at, google on to look at other logs (for education purposes) then fix .

C:\Program Files\Internet Optimizer\optimize.exe (part of what i said above)
C:\Program Files\Messenger Plus! 2\MsgPlus.exe (said to be spyware in itself)
C:\Program Files\Internet Optimizer\actalert.exe (again, dialer)
C:\WINDOWS\System32\HPZipm12.exe (don't know, and these next few look suspicious)

(google on the exes and dll names above and below and you'll want to delete the bad files after a reboot)

R3 - URLSearchHook: (no name) - _{CFBFAE00-17A6-11D0-99CB-00C04FD64497} - (no file)
O2 - BHO: (no name) - {000020DD-C72E-4113-AF77-DD56626C6C42} - C:\WINDOWS\twaintec.dll
O2 - BHO: (no name) - {9C691A33-7DDA-4C2F-BE4C-C176083F35CF} - C:\WINDOWS\System32\bridge.dll

O2 - BHO: (no name) - {F7F808F0-6F7D-442C-93E3-4A4827C2E4C8} - C:\WINDOWS\nem216.dll
O2 - BHO: (no name) - {FBED6A02-71FB-11D8-86B0-0002441A9695} - C:\WINDOWS\5_0_1browserhelper5.dll

O4 - HKLM\..\Run: [RunDLL] rundll32.exe "C:\WINDOWS\System32\bridge.dll",Load
O4 - HKLM\..\Run: [Internet Optimizer] "C:\Program Files\Internet Optimizer\optimize.exe"
O4 - HKLM\..\Run: [MessengerPlus2] "C:\Program Files\Messenger Plus! 2\MsgPlus.exe"
O4 - HKLM\..\Run: [pxroutei] C:\WINDOWS\System32\pxroutei.exe
O4 - HKLM\..\Run: [gmtapim] C:\WINDOWS\System32\gmtapim.exe
O4 - HKLM\..\Run: [pphelpa] C:\WINDOWS\System32\pphelpa.exe
O4 - HKLM\..\Run: [api32t] C:\WINDOWS\System32\api32t.exe

there are other thing not really needed to be running at startup and I may have missed something else bad.. but research and fix and then reboot, delete bad files/folders.. and post a new log.