It might be time to check out DiamondCS again. They have quite a few useful little tools in their freebies collection.
Recently, you can now get a home user free edition of "processguard". In the old days you could get a permanent trial that only protected one process. Now it is a functionally limited version where you can protect as many as you like. The product has sort of moved out of beta, so it is more or less an extended version of the old one.
Whilst you are there you might like to check "wormguard" as well.
Actually they are mentioned in a link I put in another thread. Rootkit detection, removal and protection tools are to be found here:
Most are free and quite a few of the AV "big names" are represented