It may sound weird...

ignore / delete the unwanted SPAM!

Do not respond!


From a spammers point of view.... (I'm not a spammer, never have been, never want to be!)
If you reply / flame them, to either their reply-to address or their real point of origin (read all the headers) it tells them that your email is real and working....


Then your email address will get sold onto hundreds / thousands of 'working' "Email Lists" in no time...
...you've got a tenfold increase on your own intake of Spam!

Delete the emails!
Filter them to /dev/null, whatever!!
Your wasting time trying to reply to these *****ers,
active email address's are their bread and butter.


And another note of caution..

The To: 'line' of a spam email contains a small snapshot of other poor *****ers getting the same unwanted email, look to the headers for the origin and leave the recipients alone.

If possible filter your email before you download it, if the emails are HTML'd then you also run a risk of having a 1x1 transparent image (or any of the on-line content) logging the working email on some temporary or permanent web-server.

If I wanted to see what IP your on, I send you a HTML email with a graphic uniquely referenced on my website, you read it (whilst on-line) and great... my web server log tells me that dialup.sucker.isp.com just fetched my imaginary image,

then I know...
1. Your email is working
2. You read the email
3. Your ip address for a (given period of time)
4. A good guess at your OS (if your not via proxy)

I hope this helps,

J.


PS...
My suspicion is that every single opt-out address is just an invitation to receive more unwanted shite in yer email.
Don't try an opt-address unless your over 95% confident it's legit.