Im a member of several security forums and NOD32 is a favorite on all of them (with Kaspersky Personal Pro as an alternate), I had only 2 issues with it.

1. A false positive of a backup copy of DIY DataRecovery's Repoman (DOS) Which I constantly had to kill the AMON popup for (trial version, Im sureI could have ignored it but lacked full access)

2. For some reason (and I didnt muck with my clock) My trial expired 3 days in. (Was doing a considerable amount of registry editing, and Im pretty confident that inadvertently caused it )