You can never be 100% protected from all the evil **** on the net, but your current practicies are a good first step. In addition to what the others have said, you should occasionally make some backups of your important files, just in case something screws up your box bad enough that you have to reformat. Also, running your AV and Anti Spyware in safe mode can help you find some buggers that you might've missed when running normally.