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If you have Spybot Search and Destroy immunizing your computer , you are going to run into some problems with Download managers on Internet Explorer.
Realplayer installer is made up of RealDownload 5 (legacy download manager boght out by Real Networks)
Spybot protects realtime in the background by blocking these installers and may be too strict.
If you also use Spyware Blaster , and you have everything in the bad list permanently blacklisted , this will do it for you too.
If you use them both at the same time , you will find the two programs fighting over eachother trying to protect your machine from harmful active X content which results in a connection refused error.
While its true to say that you can never not have enough protection , its pretty useless to over - restrict your computer by downloading every known spyware program out there and try to guard your computer from harmful spyware.
Ad Aware 6.0 and Spyware blaster are adequate along with a effective working virus protection software.