Quote:
\actually, they don't block pain at all. They change your perception of it. Opiates allow you to be relieved of pain while remaining concious. Something no other Pain killer is capable of. Also, you can still feel the pain, it just doesn't hurt anymore. Opiates are great for pain. you are a bit correct about the way you described it, but another great quality of Opiates is, they won't numb it like Cocain, they will make it feel different.
<cough>... excuse me... see this link -
http://www.elmhurst.edu/~chm/vchembook/674narcotic.html
specifically this quote
Quote:
The main pharmacological action of analgesics is on the cerebrum and medulla of the central nervous system. Another effect is on the smooth muscle and glandular secretions of the respiratory and gastro-intestinal tract. The precise mechanism of action is unknown although the narcotics appear to interact with specific receptor sites to interfere with pain impulses.
precise mechanism unknown (although significant strides have been made in the last few years I should point out) but appear to interact with specific receptor sites to interfere with pain impulses i.e. they block them... if you want to know its thought that opiates block the acetyl choline response
also
http://www.ch.ic.ac.uk/rzepa/mim/dru...phine_text.htm
specifically
Quote:
Its analgesic properties are related to the ability of the molecule to fit into and block a specific receptor site on a nerve cell. This eliminates the action of the pain receptor, preventing the pain signals reaching the brain. This is similar to the way in which the body's natural painkillers (endorphins and enkaphalins) work. The shape of the morphine molecule is crucial to its ability to exactly fit into the active site on the receptor - the 'lock-and-key' mechanism. The benzene group of the morphine molecule fits snugly against a flat section of the receptor protein, whilst the bent neighbouring group of carbon atoms fits into a nearby groove. This allows the positively charged nitrogen atom to attach to a negatively-charged group on the receptor, so locking the two molecules together.
directly referring to morphine I know but morphine is a derivative from opium and is also found in naturally occuring opium
direct from the encyclopaedia brittanica
Quote:
Analgesics are classified by the mechanism of their pain-relieving action as opioids (opiates and similar synthetic compounds), which act on receptors in the brain to inhibit pain impulses, or nonopioids (nonsteroidal anti-inflammatory…
Opium is an analgesic - its one of the drugs that first defined what an analgesic is......
I can give you a shed load of scientific research papers in this area if you like (I used to study pharmacology as part of my BSc) showing that opiates DO block pain. I will say that opiates DO NOT block all neural impulses so yes they will change your perceptions - this is not the same as saying that they do not block pain though. You said it yourself
Quote:
pain is still there, but it just doesn't hurt anymore
It doesn't hurt anymore because the nerves telling your brains that an area of your body is damaged and is in pain are being blocked. The reason you're still aware of damage (pain if you will although it's not correct terminology in this instance) to that area is because of the inflammation response causing pressure on other nerves in the surrounding tissue. These pressured nerves are firing response to your brains telling you thats something is causing pressure... but since the chemical response is different from pain it isn't blocked by the opium.
Gore I'm not arguing with you about the ethical or moral implications of drug use (like I said before I tend to agree with you as regards legalisation) - however I am arguing with you about the scientifc basis on which they work and frankly my friend in this area you are wrong.
I'm not questioning your own experiences but I am explaining why you are experiencing them..... if you want to carry on this topic though can we take it to PM cos I don't think everyone else would want to hear?
Z