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Have Hijack This fix the following lines:-
R3 - URLSearchHook: (no name) - _{CFBFAE00-17A6-11D0-99CB-00C04FD64497} - (no file)
O2 - BHO: RUPK - {604B283A-4E26-4504-98E7-72859F949547} - C:\PROGRA~1\HITWAR~1\sypcms.dll
O16 - DPF: {10000000-1000-0000-1000-000000000000} - file://C:\Program Files\Internet Explorer\setup.exe
If you know for sure what the second on is and that it is safe you can leave it in. Other than that your box looks pretty clean - Congratulations.....
One final note Melissa..... When you create a nickname to hide your identity when you join a forum take care when you upload files from your computer.....
C:\Documents and Settings\Melissa\My Documents\HijackThis.exe...... ;)
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HijackThis will make a log and show you whats running on your box, if u see something out of the norm, ask about it then if u need to delete it.