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The second method of injecting could be done remotely by virus usage or getting a dumb employee to run a precompiled program to preform the injection. But then what? Due to SP2 the windows system files, once loaded in memory, are unable to be modified. Most of their memory registers are also already encrypted on the spot. The only way to overwrite a windows protected system file (exe or dll based, mostly) is by rebooting the computer into Safe Mode and proceeding that way
It is possible to disable the WFP on the fly by closing the Handles that are monitored by WFP. Also the process which monitors WFP directories is actually our very same winlogon.exe. :) so I would not rely on WFP to save you, and I dont believe code execution vulnerabilities in Windows are particulalry rare. :)