SMTP is a very, nieve protocol. It trusts that you are who you say you are, which from a security (or spam) point of view is BAD. You can turn on SMTP authentication which will require users to authenticate before being able to send. Clients will need to be reconfigured to authenticate. You obviously can't block port 25, or you won't be able to send and receive email, but you should restrict your server from relaying from any IP that is not in your network. This will prevent outsiders from relaying through your server. I don't know the exact steps to do this on your specific server, but atleast the concepts should be the same.
