Re: Is this safe or not ?
Kind of old...
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7/tcp open echo
9/tcp open discard
13/tcp open daytime
17/tcp open qotd
19/tcp open chargen
These are part of the "Simple TCP/IP services". You don't need them. Remove it.
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21/tcp open ftp
25/tcp open smtp
80/tcp open http
443/tcp open https
These are part of IIS. If you don't need the smtp and http services, stop them using the IIS management console.
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42/tcp open nameserver
53/tcp open domain
DNS Server. Not sure. You may need it if you're running AD.
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515/tcp open printer
Unix printing services. Probably don't need it. Remove it.
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548/tcp open afpovertcp
AppleTalk. If you don't have any Apple computers on your network remove it.
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6666/tcp open irc-serv
Not sure about these. Could be some kind of IRC backdoor.
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7007/tcp open afs3-bos
Microsoft Streaming Media Services. If you don't need it, remove it.
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is my ports on this box safe or not what should i do to keep them close ?
No, your box is not safe. It looks like you enabled every single service possible on a W2K.
How to keep them closed? Only enable services you actually need/use.