I just recently downloaded and ran Registry Editor for the first time, and this message popped up:

An important entry has been ADDED to the registry!
HKEY=HKEY_CLASSES_ROOT
PATH=vbsfile\shell\open\command
NAME=
DATA=%SystemRoot%\System32\WScript.exe "%1"%*

How do I know if this is malicious or something legitimate? Since it was in the System32 directory and evidently affecting an executable for user-run scripts, I didn't want to make any assumptions.