Here is a bit more information on Netsky.b from Symantec:

Creates a mutex named "AdmSkynetJKIS003." This mutex allows only one instance of the worm to execute in memory.

Deletes the values:

"Taskmon"
"Explorer"

from the registry keys:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run
HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows\CurrentVersion\RunServices


Deletes the values:

"KasperskyAV"
"System."

from the registry key:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Run


Deletes the registry key:

HKEY_CLASSES_ROOT\CLSID\{E6FB5E20-DE35-11CF-9C87-00AA005127ED}\InProcServer32
Symantec has it listed as a category 3 outbreak and has posted beta definitions here.

Cheers: