http://www.eweek.com/article2/0,1759,1731474,00.asp

Howes, who maintains a privacy and security page, recommends that users infected with spyware use two or more scanners in combination, as one will often detect and remove things that others do not.
That's fairly evident from reading AO posts, most posters usually recommend a combination of scans to try. Good for us.

I guess the best protection is still common sense, a little knowledge and a secure box.