Hey, I'm over at my friends house and im trying to setup his computer, recently it started coming up with spyware and he couldn't figure out why. I have run the following programs in safemode:

Avg virus scanner
Spybot
Ad-aware
Microsoft antispyware
and a program he installed himself, Spydoctor - I question this program because I havn't heard of it, but that doesn't mean much.

I have removed about 200 malware infected files from this computer, in addition to worms, hijackers, viruses, and trojans. Spybot continuously comes up saying that 3 items could not be removed and spybot will run on next startup, but even on startup I get the same message.

I continue to have problems with this system and I dont care to reinstall windows on it, I'm wondering if there is another step or if I should just bite the bullet and reinstall?

Sys specs:
Win xp home
*prior to me installing programs*
Ad-aware
Microsoft antispyware
spydoctor
*additional programs i just installed*
AVG
Zone Alarm
Spybot S&D

One file that keeps on coming up, one that could not be removed by spybot is called PMS111x, and another file that comes back is surfsidekick.

Any help would be appreciated. Thanks