I used to use KDE with Red Hat 7.1 and 7.2, but I switched to GNOME when I got Red Hat 8. I prefer the feel of GNOME over KDE now, and to me that is the only difference. As phishphreek80 said, the only diff is the preferences, desktop, and the panel (what is known as the 'taskbar' in windows) Really, its personal preference, just play with both of them for a while and see which one you like the most.