yea some of them, but ive had one the other day which freezes up explorer.exe, yes even in safe mode...it was a pain in the ass to remove it, i dont know what it was called though
...yea just like nothingelse said you can remove most of them manually in safe mode, and just so you know it might also help you what kind of safe mode you go into - command promt, simple safe mode or with networking.