Both Spysweeper and Pestpatrol have enterprise level products. The Spysweeper product isn't too bad.

Symantec 9.0 is a piece of crap as its regards to spyware/adware. It only detects it and displays an annoying pop up box for everything it finds. It doesn't remove anything.

Take a look at iPrism by St. Bernard if you are interested in appliances. They have a pretty good web filtering appliance.