Meh, PrevX is too anal for my liking. Oooohh!!! A program added an entry to the recent files list!!!! It is teh 3v1L!!!! OMG 666!!!
My combination is fairly simple. I only run registry monitors on demand (teatimer), i.e. when I install a program or something. I have Spybot, which I run once a week or so along with AdAware and HijackThis.
For AV I use AVG 7 Free, completely updated. I update at least once every two days (yes, I'm that paranoid). I also run TDS3 about once a month or so to make sure I don't have any lurking trojans. Of late, I'm also running ClamAV about once a fortnight, just to make sure.
For a firewall, I use Kerio Personal Firewall (Free edition), completely updated as usual. I also review my ruleset around once every 10-15 days, just to make sure I haven't added something that shouldn't be there to the "Always allow" list. I also have a bunch of rules added to the packet filter that allow me to quickly enable ICMP, incoming ping and the like for when I'm using nmap, for example. My browser is of course, Firefox 1.0.
So, to summarize, I use the following products:

Anti Adware/Spyware:
Spybot S/D with TeaTimer
Adaware
HijackThis!

Antivirus/Antitrojan
AVG 7 Free
ClamAV
TDS3

Firewall
Kerio Personal Firewall 4.1.2

Browser
Mozilla Firefox 1.0 Final


The rewards for all this paranoia, is that inspite of keeping some zipped malware around, I haven't had a virus/malware infection since my old 486 got infected by the OneHalf virus in the days when I used DOS 6.22/Win 3.1

Not to mention that PDF-support in Firefox is umm... pissing me off. With every version of Firefox I've had, if you click on a PDF-link, you should be glad if Firefox doesn't totally crash on you.
I've never seen this problem, except on really low RAM systems (<=64M). Otherwise, it just takes a minute or two for Acrobat Reader to start up. Try reinstalling Acrobat Reader .

Cheers,
cgkanchi