Trend Micro Internet Security does not run in Safe Mode. I tried this last night.

Though I will take your (Und3ertak3r) suggestions under advisement, I'm not particularly thrilled with any of those software progams - I've used SpyBot and Adaware before - though I can't give a positive or negative assessment on HiJackThis.

The SPYW_ is always located in Local Settings/Temp. I've even cleared that completely, including hidden and system files (if any) and yet the message window continues to pop up.

Not only is it very strange, but highly suspicious as well. I find it difficult to believe that ONLY Trend Micro is aware of this particular virus' existance. It just doesn't seem feasible that both Norton and McAffey (probably 2 of the biggest AV companies) don't know that it even exists. I'm not putting Trend Micro down as it's found stuff that Norton has not (trial tests). I even like it better than Norton, but this is too strange for explanation.