I used to have ME on and I never had any real problems with it. However by all accounts it looks like I was one of the lucky ones. 98se is tried and true. Any problem you might get with it there is bound to be a solution somewhere on the net. Windows2k is pretty good but XP is probably a better option if for gamming. I run XP now - runs pretty well. Only games I have trouble with are my old dos ones. Most new ones run fine or have a patch available.