The thing is, 'smack my bitch up' is still a series of preprogrammed responses. The alcohol is preventing some of the more complex patterns from linking properly, so the base patterns, governing 'anger' and 'aggression' related responses, are kicking in and causing the behaviour. It's still what you're programmed to do... or rather, its still recorded events being replayed.

sickness is still limited, because we don't have an entire body here, just a brain... you'd need a brain related illness. perhaps a virus that creates random segments of the database, or messes with the weighting or linking system. It would be nasty, and hard to guard against, since it would be difficult to recover from.

Remember, this is still an emulation of the biological process, not the actual process itself...