Are you asking how you would allow users access to their profile from different computers without having to reconfigure it each time? If so, you would have to enable roaming profiles. You would do that by creating a share on a file server and put the user profiles inside. Then in the user configuration properties in AD, you can set the location of the user's profile to their profile folder on the server.

EX:

C:\profiles Shared: Users read/write,admins full control,system full control
--hax0rbot Admins full control, hax0rbot modify

Set users profile to C:\profiles\hax0rbot