Besides reg tweaking you can use X-Setup to mess up with your SO.

Want a quick hint? Get WinCommander - it's a superb file commander with a ton of features, and then disable win's desktop with X-SEtup. You will notice the diference on speed. In the begging working without desktop can seem strange, but has time goes by you'll see how fast you can do things without using the mouse..

+2 in tha box