In my opinion, Lavasoft Adaware http://www.lavasoftusa.com/software/adaware/ and Spybot Search and Destroy http://www.safer-networking.org/ are both pretty easy to use and understand to take care of your spyware problem. It was earlier brought to my attention that it is best to use BOTH, as one will cover what the other has missed. Also, read up on what moxnix, groovicus, and el-half have posted to further help you. Good luck!