Do you mean the Autorun (ie Insert Notification) isn't working.. Or the computer you cant read the contents of those CD's?

If the latter.. then In device manager (hardware tab in system properties..you didn't mention OS here that Helps Bloody heaps).. Select the CD-ROM drive right click and select uninstall.. OK out of the show and restart.. And then report back..

BUT if your problem is to do with the former (Autorun/Insert notification) Do the above anyhow.. and report back..

Cheers