First thing is to work out what the ports areused for:
eg 21=ftp
25=smtp
80=http
110=pop3 etc etc....

This is a good page: http://www.iana.org/assignments/port-numbers
Also, do netstat -a at a command prompt and see what is doing what.
Do netstat /? for a list of commands. netstat -o is a good one Then you can see PIDs that are assoc with certain ports.

What's the name of the prog you're using?