To add to meeeeeeeee's prognosis/opinion:

The biggest problem with automated scans is that they do not look at context. Take for example the following: (go ahead, you can plug them into the automated reader if you want)

O4 - HKLM\..\Run: [THG] C:\WINDOWS\system32\THGuard.exe
O4 - HKLM\..\Run: C:\WINDOWS\System32\regedit.exe
O4 - HKLM\..\Run: C:\WINDOWS\System32\explorer.exe
O4 - HKLM\..\Run: [KBD] C:\HP\KBD\KBD.EXE
O4 - HKLM\..\Run: [PS2] C:\WINDOWS\system32\ps2.exe
O4 - HKLM\..\Run: [Recguard] C:\Program Files\SMINST\RECGUARD.EXE


Can you figure out what, if anything, is wrong with those? The question then becomes, what should one do with them? Remove them and possibly damage the system? Those are legitimate files....or are they? You can find them all on Google, so they must be ok.

You will get an error message that is pretty confusing. Certainly not for a novice user, IMHO.

The other issue I have is that if you do use the scanner, and do mess something up, who are you going to get to help undo your mistake? I can see this scenario:
OP:
"I used your automated scanner, and it was unsure about some files, so I deleted them. Help me please"
HELPER:
"Do you remember what you deleted?"
OP:
"No"
HELPER:
"I can't help you because I don't know what you did..sorry. I guess you will just have to reformat. I sure hope you have your OS disks"
OP:
"What OS disks?"
At least when a mistake is made when helping someone clean their system (their mistake or mine), I am right there to help them fix it, even if it means e-mailing them the necessary files to correct the error. And it does happen from time to time.

And in addition to what meeeeeeee said about VX2, there are variants that do not show up in the log at all, as well as some variants of qooligic.

I really do appreciate the efforts people go through to keep up with these things, and to try to keep them up to date. I have designed practice logs that will fool the automated scanners just for the simple fact that I don't want those people I help train to have to depend on them (the automated readers, I mean).

Just for fun, put those entries into the reader found here:
http://www.help2go.com/modules.php?name=HJTDetective

Anyway, that's just my somewhat educated opinion.