How about emptying your temp folders?

Boot into safe mode:
Go to Start>Run> Type in cmd then type in the following:
del C:\documents and settings\sunshine\local settings\temp\*.*

That will clear most everything out of your temp folder. TrendMicro and other scanners won't remove them if they are in use. It might be a good idea to download a free AV, such as AntiVir, or AVG, and run them in safe mode. Or if you already have an onboard AV, then run it in safe mode.