The question may have been prompted by a recent US TV episode of Threshold, where a small EMP generator was used to take out all the computer-chip-based devices in a 100-mile radius of the center of Miami or something--and save the world!. Yes, you can generate an EMP and disable solid-state circuit and microchip-based technology within range of the device. To get 100-mile radius would require an immense amount of power and I doubt very much that the EMP generator capable of that kind of power would fit in a pickup (reference Electronic Devices for the Evil Genius).