Metasploit is a framework.. It has nothing to do with the exploits posted at sec.focus. The exploits found at sec.focus aren't "generated" they are posted by the user community and they may or may not use the metasploit framework. Most of them are basically used "stand-alone".

If you don't know what to do with it then you need to read up.. As Nihil said, you're trying to run before you can walk.

Start by reading up on the various ways to exploit bugs, things like buffer overflows, format string exploits, sql/command injections etc. Once you know how the basics work you can move on to the more or less "real world" scenario you're trying now.