I have used pointsec and safeguard easy in previous roles(as they are the ones approved for Govt use within Australia).

Pointsec was better as it allowed for more centralised management of Pointsec configuration and users. The version of Safeguard we were using did not provide centralised management, so anytime there was an issue an admin had to physically touch each laptop/desktop. This may have changed with later safeguard releases though (we were limited to using the Australian government approved version).

http://www.checkpoint.com/pointsec/
http://www.utimaco.com/C125748F00374.../INTERN_HomeEN