I use a variety of tools. Ccleaner isn't necessarily considered an anti-malware tool, but it cleans out temp folders and other places that malicious files like to hide. I usually follow that up with Malware bytes anti-malware, in or out of safe mode depending on the state of the computer. Then I will use combofix and or spybot S&D. Granted most of this is after the initial infection is detected, as most of these products will do nothing to prevent an infection [with the exception of spybots immunize feature]. There is no one end all be all tool for preventing and detecting infections. They all have their pros and cons.