I have been using MBAM for a while. I love it. That is usually my first attack on an infected machine [after running ccleaner, of course]. I have also been using some of the bootable rescue CDs. I hadn't used spybot in a year or more, and the definitions date confused me. Nihil cleared that up though. On occasion I will also pull out Combofix if it is a particularly nasty infection. If that combination doesn't remove all of the junk, time for an OS reinstall.